abstract：:BACKGROUND The aim of this study was to investigate the efficacy and clinical value of liraglutide for the treatment of patients with diabetes mellitus (DM) complicated by non-alcoholic fatty liver disease (NAFLD). MATERIAL AND METHODS Patients with DM complicated by NAFLD (n=835) were enrolled. Patients were divided ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang Z,Qi Y,Kong W,Jin Q,Wang X,Dong Y,Wang Y,Li H

更新日期：2018-10-16 00:00:00

abstract：:BACKGROUND Recently, miR-146a C>G, miR- 149 T>C, miR-196a2 T>C and miR-499 A>G polymorphisms have been associated with susceptibility to many diseases, including ischemic stroke (IS). However, results have been reported inconsistency in IS, especially in the Chinese population. This study aimed to investigate the poly...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhu X,Hou R,Ma A,Yang S,Pan X

更新日期：2018-10-15 00:00:00

abstract：:BACKGROUND Traditional diagnostic methods for tuberculosis (TB) cannot be reliably applied to tuberculous pleurisy. Therefore, this prospective, randomized, controlled trial was performed to compare the diagnostic sensitivity and safety of ultrasound-guided cutting-needle pleural biopsy versus thoracoscopic pleural bi...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhou X,Jiang P,Huan X,Li W,Chen Y,Gao H,Qi X,Wu J,Wang X,Ou Y,Jia X

更新日期：2018-10-10 00:00:00

abstract：:BACKGROUND Growing evidence indicates that a non-coding RNA named miR-34b/c plays crucial roles in carcinogenesis, and its common polymorphism, pri-miR-34b/c rs4938723, also participates in this process and is associated with cancer susceptibility. However, this association was previously undefined and ambiguous. Ther...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu B,Zhu Y,Tang Y,Zhang Z,Wen Q

更新日期：2018-10-04 00:00:00

abstract：:BACKGROUND Effects of liver dysfunction on target-controlled infusion (TCI) with Marsh parameters of propofol remain poorly documented. The purpose of this study was to evaluate the performance of propofol TCI in a cohort of Chinese patients with severe hepatic insufficiency. MATERIAL AND METHODS We assigned 32 patien...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chi X,Pan J,Cai J,Luo G,Li S,Yuan D,Rui J,Chen W,Hei Z

更新日期：2018-09-30 00:00:00

abstract：:BACKGROUND This study investigated the correlation of programmed death 1 (PD-1) and T cell immunoglobulin and ITIM domain (TIGIT) with clinicopathological characteristics of renal cell carcinoma (RCC) and explored the biological roles of both proteins in the development, metastasis, and invasion of RCC. MATERIAL AND M...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Hong X,Wang X,Wang T,Zhang X

更新日期：2018-09-28 00:00:00

abstract：:BACKGROUND Clogging of the suction tip frequently occurs during orthopedic surgery. We developed a novel anti-clog suction tip using 3D printing technology to improve orthopedic surgery efficiency. MATERIAL AND METHODS We studied the root causes of obstructions in suction tips currently employed in orthopedic surgery ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang J,Yang L,Ma M,Li G,Xu S,Li Q,Xu Z,Liu J,Ye C

更新日期：2018-09-25 00:00:00

abstract：:BACKGROUND Hepatitis B virus (HBV) genotypes show genomic variations, resulting in different CpG islands in each HBV genotypes or subgenotype. This study aimed to establish reference sequences for each HBV subgenotype of A-H genotypes and to analyze the characteristics of the CpG islands. MATERIAL AND METHODS There we...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen L,Shi Y,Yang W,Zhang Y,Xie Q,Li Y,Li X,Li J,Zhang Z

更新日期：2018-09-25 00:00:00

abstract：:BACKGROUND The aim of this study was to describe the clinical characteristics of Chinese ADPKD inpatients and to identify the factors associated with disease severity. MATERIAL AND METHODS We included 167 hospitalized patients (inpatients) with ADPKD in this study. Multiple regression analyses were conducted to determ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Meng J,Xu Y,Li A,Fan S,Shen X,Ma D,Zhang L,Hao Z,Zhang X,Liang C

更新日期：2018-09-16 00:00:00

abstract：:BACKGROUND The aim of this observational case-control study was to compare the levels of plasma resistin between patients with acute aortic dissection and matched controls, and to use propensity score matching (PSM) to reduce case selection bias and clinical confounders. MATERIAL AND METHODS With the use of PSM, this ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu X,Zheng X,Su X,Tian W,Hu Y,Zhang Z

更新日期：2018-09-13 00:00:00

abstract：:BACKGROUND In recent years, emerging evidence has suggested that ulcerative colitis occurs as a consequence of an imbalance between oxidative stress and antioxidant capacity. The objective of this study was to investigate whether serum total bilirubin and serum uric acid levels were associated with ulcerative colitis....

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Tian S,Li J,Li R,Liu Z,Dong W

更新日期：2018-09-09 00:00:00

abstract：:BACKGROUND In thyroid nodules with indeterminate cytology, further clinical assessment aimed at ruling out malignancy is often mandatory. Ancillary imaging techniques and genetic mutation analysis can improve the risk stratification of such lesions, thereby facilitating the clinician's decision to undertaken surgery o...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gay S,Schiaffino S,Santamorena G,Massa B,Ansaldo G,Turtulici G,Giusti M,At The Policlinico San Martino Genoa TT

更新日期：2018-09-08 00:00:00

abstract：:BACKGROUND The aim of this study was to assess the effect of combined use of Astragaloside IV(AsIV) and atorvastatin (AV) on the expression of PPAR-γ and inflammation-associated cytokines in atherosclerosis rats. MATERIAL AND METHODS High-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and low-density...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Sun B,Rui R,Pan H,Zhang L,Wang X

更新日期：2018-09-07 00:00:00

abstract：:BACKGROUND Predictive values of admission blood glucose for early hematoma expansion in patients with intracranial hemorrhage (ICH) remain controversial. Blend sign is a novel image predictor for early hematoma growth that suggests presence of active bleeding. We investigated the association between hyperglycemia and ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang F,Li H,Qian J,Tao C,Zheng J,You C,Yang M

更新日期：2018-09-07 00:00:00

abstract：:BACKGROUND The therapeutic potential of endothelial colony-forming cells (ECFCs) may be impaired in an ischemic environment. Direct injection of ECFCs is not an effective method of rescuing the ischemic heart, but exosomes derived from these cells may be a promising therapeutic tool. However, exosomes produced under n...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu W,Zhang H,Mai J,Chen Z,Huang T,Wang S,Chen Y,Wang J

更新日期：2018-09-05 00:00:00

abstract：:BACKGROUND We explored the intervention effect of a smartphone medical app on complications and quality of life of patients with nasopharyngeal carcinoma who underwent radiotherapy and chemotherapy. MATERIAL AND METHODS We divided 132 patients with nasopharyngeal carcinoma who received radiotherapy and chemotherapy fo...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Di R,Li G

更新日期：2018-09-04 00:00:00

abstract：:BACKGROUND Adenomyosis is a cause of chronic pelvic pain in women of reproductive age. The aim of this study was to investigate the effects of subcutaneous etonogestrel implantation on adenomyosis. MATERIAL AND METHODS A clinical observational study included 17 women with adenomyosis who were treated with subcutaneous...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wu J,Huang Y,Chen L,Hu J,Zou Y

更新日期：2018-09-01 00:00:00

abstract：:BACKGROUND In recent years, the incidence of gastric cancer (GC) has been increasing worldwide. Emerging evidence shows that microRNAs (miRs) may be involved in the pathogenesis of GC. Thus, this study explored the mediatory role of miR-495 in GC chemosensitivity, and investigated the mechanism by which it affects the...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li N,Han M,Zhou N,Tang Y,Tang XS

更新日期：2018-08-27 00:00:00

abstract：:BACKGROUND Parkinson's disease (PD) is a common age-related neurodegenerative disorder, but effective therapeutic agents for PD remain largely limited. MATERIAL AND METHODS In the present study, we evaluated the beneficial effects and underlying mechanisms of punicalagin (PN) in human neuroblastoma SH-SY5Y cells treat...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chu J,Han W

更新日期：2018-08-25 00:00:00

abstract：:BACKGROUND Particulate matter 2.5 (PM2.5) in air pollution is regarded as a risk factor for cardiovascular disease (CVDs). Recently, it has become well accepted that polycyclic aromatic hydrocarbons (PAHs) in PM2.5 impacts human CVDs. However, few studies have shown miRNAs affected by PAHs play a critical role in tran...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： He X,Chen Y,Zhang C,Gong W,Zhang X,Nie S

更新日期：2018-08-25 00:00:00

abstract：:This paper is being retracted based on publishers' legal criteria. We have received notification from the author, Yonghui Shen, that he had added Dr. Wei Zhang (the first author) as a co-author fraudulently, without his permission or authorization, and that he falsified the confirmation from Dr. Zhang. Dr. Wei Zhang h...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang W,Chen L,Jiang Y,Shen Y

更新日期：2018-08-24 00:00:00

abstract：:BACKGROUND Cryptorchidism is the most common developmental abnormality of the male reproductive system. If left untreated, it results with infertility and testicular cancer. According to current evidence, surgery is the mainstay of treatment, and hormonal therapy approaches are still under investigation. For the prote...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Biçer Ş,Gürsul C,Sayar İ,Akman O,Çakarlı S,Aydın M

更新日期：2018-08-21 00:00:00

abstract：:BACKGROUND Bone neoplasms are common in humans and have high lethality. Recently, great progress has been made in understanding the pathophysiological mechanisms, but little is known about the molecular and genetic networks involved. MATERIAL AND METHODS qRT-PCR assays were conducted to detect the expression levels of...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang T,Wan CY,Mei XL,Jia P,Wang MJ

更新日期：2018-08-18 00:00:00

abstract：:BACKGROUND This study aimed to investigate the correlation of brain perfusion with white matter hyperintensity (WMH), brain atrophy, and cognition in patients with moderate to severe posterior cerebral artery stenosis (PCAS). MATERIAL AND METHODS 65 patients with memory decline as the main complaint and no history of ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu M,Nie ZY,Li RR,Zhang W,Wang H,He YS,Zhao LJ,Li YX

更新日期：2018-08-17 00:00:00

abstract：:BACKGROUND Short dental implants are considered an alternative method of treatment to the maxillary sinus elevation and bone augmentation procedure at the sites of a reduced alveolar ridge height. The aim of the study was to determine the most effective therapeutic approach for a single tooth replacement in a reduced ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Hadzik J,Krawiec M,Kubasiewicz-Ross P,Prylińska-Czyżewska A,Gedrange T,Dominiak M

更新日期：2018-08-14 00:00:00

abstract：:BACKGROUND Breast cancer is a malignant tumor derived from breast gland epithelium. The screening and early diagnosis of breast cancer in high-risk populations can effectively suppress its threat to women's health and improve treatment efficiency, and thus has critical importance. Using various evaluation models, the ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang L,Jie Z,Xu S,Zhang L,Guo X

更新日期：2018-08-09 00:00:00

abstract：:BACKGROUND Asiatic acid (AA; 2α,3β,23-trihydroxyurs-12-ene-28-oic acid) is an active compound derived from Centella asiatica, a traditional medicinal plant used widely in many Asian countries, particularly for the treatment of cancer. However, the modified AA derivative N-(2α,3β,23-acetoxyurs-12-en-28-oyl)-l-proline m...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang G,Xiao Q,Wu W,Wu Y,Wei Y,Jing Y,Gong Z

更新日期：2018-08-04 00:00:00

abstract：:BACKGROUND Studies on monoamine oxidase B (MAO-B) expression in renal cell carcinoma (RCC) are lacking. This study focused on the immunohistochemical evaluation of MAO-B in RCC. MATERIAL AND METHODS Sixty-three RCC samples were compared on basic clinical and histopathological parameters, including histopathological ty...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Hodorová I,Rybárová S,Solár P,Benický M,Rybár D,Kováčová Z,Mihalik J

更新日期：2018-08-04 00:00:00

abstract：:BACKGROUND The aim of this study was to analyze the differences in vaginal microecological factors and genital tract infections among pregnant women of different ages. MATERIAL AND METHODS This study included 751 pregnant women from West China Second University Hospital, Sichuan University, China, from January 2015 to...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu F,Tang YT,Hu ZQ,Lin XN

更新日期：2018-08-01 00:00:00

abstract：:BACKGROUND Few investigations have been reported on the changing trends in transmission routes of hepatitis C virus (HCV) and the corresponding HCV genotype (GT) distribution in Hunan province, China. MATERIAL AND METHODS HCV GTs, suspected viral transmission routes, and time of initial infections were investigated in...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Lei JH,Liang J,Gong X,Xiao XQ,Chen Z,Peng F

更新日期：2018-07-28 00:00:00

abstract：:BACKGROUND G protein-coupled receptor 110 (GPR110) belongs to the subfamily of the adhesion G protein-coupled receptors (GPCRs). The potential role of GPR110 has been correlated with cancer cell invasion in some tumors such as glioma. However, its expression and role in human osteosarcoma has not been identified. This...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu Z,Zhang G,Zhao C,Li J

更新日期：2018-07-27 00:00:00

abstract：:BACKGROUND We studied the expression and effect of miR-26a-5p in synovial fibroblast in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS The synovial tissues of 55 RA patients with total knee arthroplasty performed from January 2016 to December 2016 were collected as the RA group, and 62 patients without ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang W,Chen L,Jiang Y,Shen Y

更新日期：2018-07-26 00:00:00

abstract：:BACKGROUND The anti-microbial protein cathelicidin LL-37 plays an important role in the pathogenesis of psoriasis by inducing inflammation. Our previous study showed that the chlamydial plasmid-encoded protein pGP3 forms a stable complex with LL-37 to neutralize its pro-inflammatory activity. Here, we explored whether...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Hou S,Xu R,Zhu C,Shan S,Han L,Wang H

更新日期：2018-07-25 00:00:00

abstract：:BACKGROUND Cardiac infarction frequently leads to arrhythmia and ischemia/reperfusion (I/R) aggravates cardiac injury. Pinocembrin can resist cerebral ischemia and decrease cardiac infarction area. This study thus generated a rat myocardial I/R model to assess the effect on ventricular rhythm and expression of gap jun...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang P,Xu J,Hu W,Yu D,Bai X

更新日期：2018-07-19 00:00:00

abstract：:BACKGROUND Collapsin response mediator protein-2 (CRMP-2) is the first member of the CRMP family that has been identified in primary neuronal cells; it was originally found and identified in the regulation of microtubule dimerization into microtubules. MATERIAL AND METHODS In the present study, we aimed to investigate...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： He J,Zhu J

更新日期：2018-07-18 00:00:00

abstract：:BACKGROUND The aim of this study was to compare the clinical outcome in patients with pancreatic ductal adenocarcinoma who underwent frozen section and paraffin section histology of the surgical resection margins during pancreaticoduodenectomy. MATERIAL AND METHODS Frozen section and routine paraffin section histopath...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Dikmen K,Kerem M,Bostanci H,Sare M,Ekinci O

更新日期：2018-07-15 00:00:00

abstract：:BACKGROUND Lysophosphatidic acid (LPA) is an active compound of oxidized low-density lipoprotein that serves as an endogenous TLR4 ligand. Ligand activation of TLR4 activates nuclear factor-kappaB (NF-κB) and the transcription of NF-κB-regulated inflammatory cytokines, which are involved in the development of atherosc...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhou ZB,Yang B,Li X,Liu H,Lei G

更新日期：2018-07-13 00:00:00

abstract：:BACKGROUND Sepsis causes the highest mortality in non-cardiovascular intensive care units worldwide. Recent research has demonstrated that the late phase of sepsis, characterized as septic immunosuppression, is the central pathophysiological mechanism of immune dysfunction. Investigating the suppressive mechanism of i...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhou Y,Xia Q,Wang X,Fu S

更新日期：2018-07-11 00:00:00

abstract：:BACKGROUND The aim of this study was to examine the effects of the natural flavonoid, quercetin, in a rat model of adenine-induced chronic kidney disease. MATERIAL AND METHODS Forty male Wister rats were divided into four groups: normal (no adenine or quercetin) (n=10); untreated model (treated withadenine but not que...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yang H,Song Y,Liang YN,Li R

更新日期：2018-07-10 00:00:00

abstract：:BACKGROUND Endometrial carcinoma (EC) is a type of female reproductive malignant tumor, the incidence of which is generally 20~30%. Multiple factors and genes are involved in the regulation of EC occurrence and progression. This study aimed to measure the expressions of MACC1 and c-Myc in EC patients to analyze their ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang Q,Xu P,Lu Y,Dou H

更新日期：2018-07-09 00:00:00